ABSTRACT
Flavonoids from Dolichos biflorus Linn, were isolated and screened for antilipidemic activity on rabbits fed with high fat diet [HFD]. Methanolic extract of Dolichos biflorus was fractionated with hexane, chloroform, ethyl acetate and methanol. Ethyl acetate fraction which showed maximum flavonoid yield, was fractionated by column chromatography and estimated for flavonoids [total phenol] content. High fat diet rabbits showed significantly increased level of plasma and tissue total cholesterol, triglyceride, free fatty acids, phospholipids, plasma LDL cholesterol and decreased level of plasma HDL cholesterol. Administration of isolated flavonoids from Dolichos biflorus to high fat diet rabbits showed near to normal [control] level of the above lipid profiles in plasma and tissues. Hence it is concluded that flavonoids of Dolichos biflorus possess antilipidemic activity in high fat diet fed rabbits